{"id":27977,"date":"2024-10-11T06:36:45","date_gmt":"2024-10-11T06:36:45","guid":{"rendered":"https:\/\/leadersinsport.com\/performance-institute\/?post_type=article&p=27977"},"modified":"2025-12-15T05:10:51","modified_gmt":"2025-12-15T05:10:51","slug":"how-one-company-is-working-to-reduce-the-risk-of-fibrosis-in-following-knee-surge","status":"publish","type":"article","link":"https:\/\/leadersinsport.com\/performance-institute\/articles\/how-one-company-is-working-to-reduce-the-risk-of-fibrosis-in-following-knee-surge\/","title":{"rendered":"How One Company Is Working to Reduce the Risk of Fibrosis in Following Knee Surgery"},"content":{"rendered":"\n\n
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\n 11 Oct 2024 <\/p>\n \t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/span>Articles<\/a>\n\n\t\t\t\t\t\t

How One Company Is Working to Reduce the Risk of Fibrosis in Following Knee Surgery<\/h1>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\n \n\t\t\t<\/div>\n\t\t<\/div>\n\n\t<\/div>\n<\/div>\n
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Category<\/div>\n Data & Innovation<\/a> <\/div>\n
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https:\/\/leadersinsport.com\/performance-institute\/articles\/how-one-company-is-working-to-reduce-the-risk-of-fibrosis-in-following-knee-surge\/<\/div>\n <\/div>\n <\/div>\n <\/section>\n\n\n\n\n
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TempleOrthotics believe their proprietary compound could be the crucial difference in helping a player return to their peak post-ACL injury.<\/p>\n \n \n \n

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A Data & Innovation article brought to you by<\/p>\n

\"sport<\/h6>\n
By Joe Lemire<\/h6>\n
A pharmaceutical company based in Belgium and New York, Temple OrthoBiologics, is launching today with a treatment that shows promising of reducing the formation of fibrosis \u2014 also known as scar tissue \u2014 that can complicate recovery from injury and surgery. It will initially focus on helping athletes and others with knee problems, particularly ACL surgeries.<\/h6>\n

Temple OrthoBiologics<\/a>\u00a0has created a proprietary compound called TX-33 that has shown good results in preventing fibrosis in abdominal and pelvic surgeries and is on track for human trials in knees as part of the FDA approval process in late 2025 or early 2026.<\/p>\n

ACL tears rank among the most devastating injuries to athletes, particularly among girls and women, typically requiring a year of rehab and no guarantee of a full return to pre-injury performance. Understanding the mechanism of injury is a growing focus among researchers, with\u00a0FIFPRO and the Women\u2019s Super League<\/a>\u00a0among those who recently commissioned a study.<\/p>\n

Temple OrthoBiologics is announcing its formation on International Arthrofibrosis Awareness Day. It has been privately by its co-founders to date.<\/p>\n

\u201cWe have a technology that can make a difference in the knee,\u201d said Temple OrthoBiologics CEO Sanj Singh. \u201cThe scar tissue that forms in the knee does several things. It prohibits proper function. The stiffness leads to pain and also inhibits good rehab.\u201d<\/p>\n

Renowned orthopedic surgeon Dr. Riley Williams \u2014 who practices at the Hospital for Special Surgery and leads surgical care for the Brooklyn Nets, New York Liberty and New York Red Bulls \u2014 is such a strong supporter of the drug\u2019s potential that he joined as a co-founder.<\/p>\n

Williams said he completes between 100 and 115 ACL reconstructions annually. The typical post-operative scar rate is 4-5%, but he noted the importance of reducing it further because, among his patients, \u201cthat\u2019s four people\u201d who might have that excessive scar response.<\/p>\n

\u201cThe formation of scar in and around these surgeries is a very poorly understood phenomena, but it has real-life consequences in surgery,\u201d Williams said, adding: \u201cIt’s very exciting because that in a very clean and unfettered way can help to dampen that [inflammatory] response without dampening the natural immune response.\u201d<\/p>\n

TX-33 can be injected after an injury or at the time of surgery and, by inhibiting excessive scar tissue from forming, healthy tissue can regenerate instead. Williams predicted that, following a successful trial and FDA approval, it will \u201cbecome standard care very quickly.\u201d<\/p>\n

Another orthopedic surgeon backing the Temple drug is Dr. Vinod Dasa, who chairs the orthopedic surgery department at LSU, and has joined the company as an advisor.<\/p>\n

\u201cFrom a sports perspective, reducing scar tissue will definitely enhance return to play and faster recoveries,\u201d Dasa said. \u201cIf it’s an issue in terms of scar formation, in terms of that ligament healing after a sports injury, maybe this will allow that natural healing to progress more appropriately.\u201d<\/p>\n

Retired Canadian Olympic bobsledder Neville Wright, who now owns and operates Wright Performance & Therapy, is a speed consultant and trainer for the Canadian men\u2019s World Cup team who now advises Temple OrthoBiologics. (Bobsledder Emily Renna<\/a>\u00a0is the other athlete advisor.)<\/p>\n

\u201cSurgery is always a fear for a lot of athletes.\u201d Wright said, noting the concern of post-traumatic osteoarthritis and its impact on full-fledged return to performance. \u201cIf I’m off a degree in regards to flexion of my knee, that can be a difference of running a really fast time to being outside of that high-performing category.\u201d<\/p>\n

Interest in sports is acute, but there is broader potential to help the general population, particularly with total knee replacements. \u201cThe age demographic of arthritis is slowly moving to the left,\u201d Dasa said, referring to a trend of younger patients needing interventions.<\/p>\n

Big Pharma doesn\u2019t typically get involved in orthopedics, he added, noting the large opportunity for a drug like Temple\u2019s. Dasa also noted that \u201cnon-surgical management of arthritis has essentially been non-existent. The lack of treatment options has implications on particular demographics, too.<\/p>\n

\u201cWe see differences in fibrosis based on health disparities, so based on race, socioeconomic status, and a few other things,\u201d Dasa said. \u201cSo if we can improve fibrosis, we may actually improve some of the health inequities and disparities that we see as well.\u201d<\/p>\n

This article was brought to you by SBJ Tech<\/strong>, a Leaders Group<\/strong> company. As a Leaders Performance Institute<\/strong> member, you are able to enjoy exclusive access to SBJ Tech<\/strong>\u00a0content in the field of athletic performance.<\/em><\/p>\n<\/p>\n <\/div>\n \n \n \n <\/div>\n

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